Myasthenia gravis-02

ʻO ka moʻolelo lapaʻau ʻo Myasthenia Gravis ʻo Li Ming

Ua hoʻomaka ʻo Li Ming, he kumu 35 makahiki, e ʻike i nā hōʻailona o ka myasthenia gravis (MG) ʻekolu makahiki i hala. I ka hoʻomaka ʻana, ʻike ʻo ia i ka ptosis (ke hāʻule ʻana o nā lihilihi) a me ka paʻakikī o ka ʻōlelo ʻana, akā ua hele mālie nā hōʻailona a hiki i ka nāwaliwali o ka ʻiʻo maʻamau, me ka paʻakikī o nā hana o kēlā me kēia lā. ʻOiai ka mālama ʻana i nā ʻano lapaʻau like ʻole, me nā steroids a me nā immunosuppressants, ʻaʻole mālama ʻia kāna mau hōʻailona.

Ma o ka hoʻolauna ʻana o kahi hoaaloha, ua hōʻea ʻo Li Ming i ka Halemai Lu Daopei e komo i kahi hoʻokolohua lapaʻau CAR-T. Ua alakaʻi kahi hui o nā loea i kahi loiloi kikoʻī o kāna mau hōʻailona a hoʻomākaukau iā ia no ka lāʻau lapaʻau CAR-T.

Kaʻina Hana:

1. Māhele Hoʻomākaukau: Ma mua o ka mālama ʻana, ua hana ʻo Li Ming i kahi loiloi olakino holoʻokoʻa. Ua hoʻokaʻawale nā ​​kauka i nā cell T mai kona kino a ua hoʻololi ʻia lākou i loko o ka hale hana e hōʻike i nā mea hoʻokipa antigen chimeric (CAR) e kuhikuhi ana i nā antigens pili i ka myasthenia gravis.

2. Hoʻonui Cell: Ua hoʻonuiʻia nā pūnaewele CAR-T i hoʻololiʻia i loko o ka hale hana e hōʻoia i kahi helu kūpono no ka mālamaʻana.

3. Preconditioning Chemotherapy: Ma mua o ka CAR-T cell infusion, ua hana ʻo Li Ming i kahi pule chemotherapy lōʻihi no ka hoʻemi ʻana i ka helu o nā lymphocytes e loaʻa nei i loko o kona kino, e hana ana i kahi ʻoi aku ka maikaʻi no nā cell CAR-T e hana pono.

4. CAR-T Cell Infusion: Ma hope o ka pau ʻana o ka chemotherapy, ua mālama ʻia ʻo Li Ming i ka haukapila no ka loaʻa ʻana o ka infusion cell CAR-T. Ua mālama ʻia kēia kaʻina hana ma lalo o ka nānā pono ʻana e pale i nā hopena ʻaoʻao.

Nā hopena lapaʻau:

1. Pane no ka wā pōkole: I ka pule mua ma hope o ka infusion, ua ʻike ʻo Li Ming i ke kuni maʻalahi a me ka luhi, nā hopena pōkole maʻamau i ka CAR-T cell therapy. ʻElua pule ma hope mai, ua hoʻomaikaʻi nui ʻia kona ptosis a me ka paʻakikī o ka ʻōlelo ʻana, a hoʻomaka ka hoʻi ʻana o kona ikaika.

2. Hoʻomaikaʻi i ka wā waena: ʻElua mahina ma hope mai, ua hoʻemi nui ʻia nā hōʻailona o Li Ming. Ua hiki iā ia ke hoʻomau i nā hana aʻo maʻamau, ʻoi aku ka maikaʻi o kāna hana, a ua hōʻike ka maikaʻi o kona ola.

3. Nā hopena lōʻihi:ʻekolu mahina ma hope o ka mālamaʻana,ʻaʻole i hilinaʻi houʻo Li Ming i nā lāʻau lapaʻau mua. Ua hōʻike ʻia nā hoʻokolohua ma hope ua maikaʻi kona ʻōnaehana pale, me ka ʻike ʻole ʻia o nā hopena koʻikoʻi.

Ma o CAR-T cell therapy, ua hoʻomalu nui ʻia ka myasthenia gravis o Li Ming. "Mahalo nui wau i ka lāʻau lapaʻau CAR-T a me ka hui lapaʻau i hoʻolaʻa ʻia no kā lākou hoʻoikaika ʻana," wahi a Li Ming me ka waimaka, e lulu lima ana i ke kauka i ka wā i hoʻokuʻu ʻia ai.