Junaid----Acute B-lymphocytic Leukemia (B-ALL)

ʻO CAR-T hoʻāʻo hoʻāʻo hoʻāʻo ʻana i ke alahaka o ka iwi iwi i ka hoʻololi ʻana i ka maʻi maʻi B-ALL me ka manuahi ma ka Halemai Lu Daopei.

ʻElima mau makahiki i hala aku nei, he haumāna ʻo Junaid ma Pakistan Medical University, piha i ka manaʻo e lilo i kauka. Akā i Mei 2014, ua ʻike ʻia ʻo ia me ka maʻi maʻi B-lymphocytic leukemia a ua haʻalele ʻo ia i kāna mau haʻawina.

Ua mālama ʻia ʻo ia ma ka ʻāina no ʻelua mau makahiki. I Ianuali 2018, ua hoʻomohala hou ʻo ia i ka ʻeha o ka iwi a ua hōʻike ʻia kahi hōʻike ʻana o ka iwi iwi ua hoʻi hou ʻo ia. Ma hope o ka papa ʻelua o ka chemotherapy ma ka haukapila kūloko, ʻaʻole hiki iā ia ke loaʻa ke kala ʻana a ua holomua ka maʻi. Ma o ka ʻimi pūnaewele a me ka ʻōlelo aʻoaʻo o nā maʻi ʻē aʻe, ua hoʻoholo lākou e hele mai i ka Halemai ʻo Lu Daopei no ka hoʻokolohua hoʻokolohua CART kiʻekiʻe a me BMT.

Ma ka 26 Malaki 2018, hele mai ʻo Junaid a me kona ʻohana i Kina a ua hoʻokomo ʻia i ke keʻena hematology nui o ka Halemai Lu Daopei. Ua hana ʻo Dr Peggy Lu lāua ʻo Dr Junfang Yang i kahi loiloi piha o Junaid. Ua hōʻike ʻia nā hōʻike he 69% ke kiʻekiʻe o ka pahū o ka iwi iwi a ua loaʻa iā ia nā maʻi pulmonary fungal. Ma hope o ka mālama pono ʻana, ua kūpaʻa ka maʻi. Ma ka 24 ʻApelila 2018, ua hoʻokomo hou ʻia ʻo Junaid me nā pūnaewele CD19 & CD22 CAR-T ʻelua. Ma hope o ʻelua pule, he 0 ka helu ʻana o ka ʻōpū o ka iwi. E hoʻopaʻa ʻia ʻo Junaid i ka BMT e lilo i maʻi ʻole.

Ma ka 25 Iune 2018, ua hana ʻo Dr Yue Lu, ka luna o ke keʻena BMT, a me ka hui lapaʻau o Dr Fang Xu i ke kaikunāne BMT no Junaid. ʻO ka mea hāʻawi iā Junaid kona kaikaina. ma ka lā 6 Iulai, ua hoʻokomo hou ʻia ka mea hāʻawi aku i loko o Junaid, ma hope o nā lā he 17 ua hoʻopau ʻia ka hoʻololi ʻana o ke koko keʻokeʻo a neʻe ʻo ia i waho o ka luminar flow ward. Ma hope o 24 mau lā, pili loa kona ʻano iwi iwi me ke ʻano iwi iwi hāʻawi. ʻAʻole maikaʻi ka nānā ʻana i ka hōʻike koena o ka iwi iwi, me ka ʻole o nā hoʻopiʻi mua pili i ka transplant. Ma ka 6 ʻAukake 2018, ua hoʻokuʻu ʻia ʻo Junaid mai ka haukapila a hoʻomaka i ka hahai ʻana ma waho.

ʻO ka hui koko Kina ke kākoʻo paʻa o ka mea maʻi ʻo Junaid ʻo RH kino ʻano ʻano koko, ʻo ia ke ʻano koko kakaʻikahi. Ua ʻae ʻo ia i "Lang Fang rare blood type alliance" hāʻawi koko manuahi no nā manawa he nui i ka wā o kona hoʻokipa ʻana. ʻAʻole like me ka nele o ka hoʻokomo koko iā ia, mahalo nui ʻo Junaid a me kona ʻohana i ke kikowaena honua no ka hana ʻana i kēia mau mea no Junaid. I kēia manawa, ua hele pū nā limahana o ke kikowaena honua me Junaid a me kona ʻohana mai ko lākou pae ʻana a hiki i kēia manawa, hāʻawi iā lākou i ke kākoʻo ola āpau a kōkua i ka ʻohana e lanakila i ka pale ʻōlelo.

ʻO ka hoʻokolohua lapaʻau CAR-T e hoʻopili iā BMT e hana i kahi hana mana hou. ʻO ke keʻena o BMT o ka Halemai Lu Daopei kekahi o nā kikowaena ikaika loa o BMT ma ka honua. ʻO Junaid ka lua o ka maʻi maʻi leukemia B-lymphocytic acute a me refractory mai Pakistan e loaʻa i ka lāʻau CAR-T Bridge BMT. ʻO ka hoʻokuʻu kūleʻa ʻana o Junaid mai ka haukapila e hōʻailona hou ana i ka ʻike honua i ka ʻenehana holomua o kā mākou haukapila o ka hoʻololi ʻana i ke alahaka CAR-T.