FAQ-Lapaʻau

Q.
He aha ke koko a me ka iwi iwi (BMT)?

A.

ʻO ka hoʻololi ʻana i ke koko a me ka iwi iwi he ʻano lapaʻau kūikawā no ka poʻe me kekahi ʻano maʻi kanesa a i ʻole nā maʻi iwi iwi ʻē aʻe. I loko o kahi hoʻololi ʻana i ke koko a me ka iwi iwi, lawe ʻia nā cell i loaʻa maʻamau i ka iwi iwi, hoʻomākaukau a hoʻihoʻi ʻia i ka mea maʻi a i ʻole kekahi kanaka. ʻO ka pahuhopu o ka hoʻololi ʻana i ke koko a me ka iwi iwi, ʻo ia ka hāʻawi ʻana i nā pūnaewele iwi iwi ola kino ma hope o ka wehe ʻia ʻana o kā lākou iwi iwi ponoʻī ʻole.

Ua hoʻohana maikaʻi ʻia ka hoʻololi ʻana i ke koko a me ka iwi iwi mai ka makahiki 1968 no ka mālama ʻana i nā maʻi e like me ka maʻi leukemia, lymphoma, anemia aplastic, nā maʻi immunodeficiency a me kekahi mau maʻi maʻi ʻaʻai paʻa.
Q.
He aha ka lōʻihi o ka noho ʻana o ka haukapila no BMT?

A.
No ka hoʻololi ʻana i ka iwi iwi i manaʻo ʻia he 4-6 mau pule ka noho ʻana i ka haukapila. Eia nō naʻe, koi ʻia ʻoe e noho i loko o ke kūlanakauhale no ka liʻiliʻi o 6 mau mahina no ka mea e koi ʻia ka hahai ʻana ma hope o ka BMT.
Q.
ʻO wai ka mea hiki ke pōmaikaʻi mai ka hoʻololi ʻana i ke koko a me ka iwi iwi (BMT)?

A.
ʻO kēia nā maʻi maʻamau ka loaʻa ʻana o ka pōmaikaʻi mai ka hoʻololi ʻana i ke koko a i ʻole ka iwi iwi:

- Leukemia

- Anemia aplastic koʻikoʻi

- Lymphomas

- Nui ka myeloma

- nā maʻi ʻaʻai kino
Q.
He aha ka CAR-T therapy?

A.
ʻO ka chimeric antigen receptor T (CAR-T) cell therapy kahi lapaʻau hou no nā ʻano maʻi maʻi. ʻO ka manaʻo ʻo ka wehe ʻana i nā pūnaewele T o ka mea maʻi a ʻenekinia iā lākou e hōʻike i kahi mea hoʻokipa antigen chimeric (CAR) e ʻike ana i kahi antigen pili i ka tumo (TAA). ʻO ka hopena, i ka wā e hoʻokomo hou ʻia ai nā pūnaewele T e hōʻike ana i ka CAR i loko o ke kino o ka mea maʻi, e hoʻopaʻa ʻia a hoʻopau lākou i nā cell tumor e hōʻike ana i ka TAA.
Q.
ʻO wai ka poʻe maʻi e pōmaikaʻi mai ka CAR-T?

A.
ʻO ka hoʻāʻo hoʻokolohua CAR-T no nā poʻe maʻi me ka maʻi leukemia lymphoblastic acute B-cell (B-ALL), lymphoma B-cell a me ka myeloma lehulehu i hoʻi hou a lilo i refractory i ka chemotherapy.
Q.
Pehea ka lōʻihi e noho ai mākou i ka haukapila no CAR-T?

A.

ʻO ka hoʻokolohua lapaʻau CAR-T ma kahi o 6-8 mau pule, pili ia i ke kūlana o kēlā me kēia maʻi.
Q.
He aha ke kaʻina hana lapaʻau o CAR-T?

A.
Q.
ʻEhia CAR-T āu i hana ai?

A.
Mai ka makahiki 2015, ua hoʻopau mākou ma kahi o 300 CAR-T mau hoʻokolohua lapaʻau no ka refractory relapsed B-ALL, B-cell lymphoma a me ka myeloma lehulehu me nā hopena maikaʻi loa. Ua hōʻuluʻulu mākou i nā hihia 51 mua a paʻi iā lākou ma ka Journal of Leukemia ma 2017.
Q.
He aha kāu helu kūleʻa CAR-T?

A.
ʻOi aku ka nui o ke kala kala ʻana ma mua o 90%.
Q.
He aha ka pōmaikaʻi o ka hoʻololi ʻana i ka iwi iwi (BMT) ma hope o CAR-T?

A.
ʻOiai ke kiʻekiʻe o ke kala kala piha (CR) o ka mālama ʻana iā CAR-T, aia nō ka pilikia o ka hoʻi hou ʻana. Ua hōʻike ʻia nā haʻawina ʻo ka hoʻopili ʻana i ka BMT ma hope o CAR-T no B-ALL hiki ke hoʻonui i ka nui o ka lāʻau lapaʻau.
Q.
Pehea e loaʻa ai iaʻu kahi hālāwai?

A.
Hiki iā ʻoe ke loaʻa kahi manawa ma o kā mākou mau ʻelele ʻoihana honua.
Q.
He aha nā palapala e lawe pū ai au?

A.
He mea koʻikoʻi loa i ka wā e hele ai ʻoe e loaʻa iā ʻoe nā palapala kūpono āpau me ʻoe me ka kope paʻa o nā hōʻike olakino āpau, nā hōʻike pathology me nā kiʻi aniani a me nā poloka paraffin e koi ʻia no ka loiloi, nā hopena kiʻi o CT, MRI, PET- CT scan, maʻamau koko, immune histochemistry, hoʻāʻo genetic, hopena chromosome inā loaʻa.
Q.
ʻO wai ka mea nāna e mālama i kaʻu mau koho a me kaʻu papa manawa i ka haukapila?

A.
E hoʻopaʻa kā mākou hui International i nā koho a hoʻonohonoho i nā mea hahai no ʻoe i kou wā i ka haukapila.
Q.
He aha ke kaʻina hana no ka poʻe maʻi e ʻimi i ka ʻōlelo aʻoaʻo olakino?

A.
Ke manaʻo nei kā mākou limahana International Center e hāʻawi i ke ala kūpono a me ka mālama pilikino no kā mākou mau maʻi maʻi honua. Loaʻa kā mākou limahana e kōkua i nā maʻi āpau ma nā pae āpau o kā lākou mālama.
Q.
Hiki iaʻu ke loaʻa kaʻu hōʻike hihia ma hope o ka mālama ʻana?

A.
ʻAe, ma hope o ka mālama ʻana, e unuhi mākou i kāu hōʻike hihia a hāʻawi iā ʻoe i kahi hōʻike hihia ma ka ʻōlelo Pelekania a me ka Pākē i hiki ai iā ʻoe ke hoʻihoʻi i kou ʻāina.
Q.
E kōkua anei kekahi iaʻu e hele i ke kahua mokulele ke hoʻi au i ka home ma hope o ka mālama ʻana?

A.
ʻAe, e mālama kā mākou limahana International Center i ke kaʻa a kōkua iā ʻoe e hoʻokomo i kāu ukana i loko o ke kaʻa a lawe iā ʻoe i ke kahua mokulele.