Bjørn Simensen----Multiple Myeloma (IgG lambda) ISS-II

Hoʻomaikaʻi! He mea maʻi mai Norewai, ʻo Bjørn Simensen, me ʻelua makahiki o ke kala mau ʻana.

Ua hōʻike ʻia ʻo Bjørn Simensen, 67 makahiki i ka haukapila i Kepakemapa 2017 me nā hoʻopiʻi o ka ʻū a me ka ʻeha o ka umauma. I ka wā o kāna hana ʻana, ua ʻike ʻia ʻo ia ka nui o ka myeloma (IgG lambda) ISS-II. Ua loaʻa i ka mea maʻi he 4 mau manawa o ka bortezomib, lenalidomide a me ka dexamethasone chemotherapy. Ma hope o 4 mau pōʻaiapuni, ua emi kona protein M ma mua o 1g/l. ʻO ka mea maʻi ma waho o ka mālama ʻana i ka lenalidomide (10mg qdx3 pule i kēlā me kēia mahina m) i hoʻomau ʻia no nā makahiki 2 e hiki mai ana. Ua noho ʻo ia me ka maʻi ʻole a hiki i ke kauwela o 2021 i ka wā o ka loiloi kala ʻana i ʻike ʻia ua hoʻonui ʻo ia i ka protein M (5g/l). Ua kāpae ʻia ʻo Lenalidomide a ua hoʻomaka ʻia ʻo ia ma ka carfilzomib a me daratumumab chemotherapy mai ʻOkakopa a Dekemaba 2021. Akā naʻe, ʻaʻole maikaʻi ka chemotherapy a ua maikaʻi ka post-chemo BM MRD.

Ua ʻike mua ʻia ʻo Mr Bjørn Simensen ma ka Halemai ʻo Lu Daopei i ka lā 14 Pepeluali 2022. Ua hōʻike ʻia kāna BM MRD i ka 0.25 pākēneka o nā pūnaewele plasma abnormal. Ua hōʻike ʻo IEF i ka protein IgG a me M he 3 g/l. Ua hōʻike ʻo PET-CT Scan i ka piʻi nui ʻana o ka hōʻike ʻoi aku ka pololei i hoʻonui ʻia ma ka hoʻokolokolo. Ua hoʻokō ʻia kahi biopsy testicular e hōʻike ana i nā cell plasma malignant. Ua koho ʻia ka mea maʻi no ka CART cell therapy. Hana ʻia ka preconditioning me ka fludarabine a me ka cyclophosphamide no 3 mau lā. Ua hoʻokomo ʻia nā kelepona CAR-T i ka lā 0 (4/3/2222). ʻO 0.5X10^6 ka nui i hāʻawi ʻia. Ma hope o ka infusion, ua loaʻa ka maʻi i ka neutropenia fever i hoʻomalu ʻia me nā lāʻau antibiotic iv. Hoʻemi mālie ka pehu testicular ʻākau i ka nui maʻamau. Ma ka lā 28 ʻaʻole maikaʻi ka hoʻokolokolo BM no nā cell plasma. Ua hoʻokuʻu ʻia ka mea maʻi mai Lu Daopei me ka mālama mau ʻana i ke kikowaena hematology ma kona kūlanakauhale.