Leukemia Lymphoblastic Acute (T-ALL)-10

He keikikāne 13 makahiki i kapa ʻia ʻo Yangyang mai Panzhihua, Sichuan Province, i loaʻa i ka CAR-T a ukali ʻia e ka hoʻololi ʻana.

Ua hōʻike mua ʻia ʻo Yangyang me "nā ʻeha ʻeha ma ke kino a me ka luhi" i ka lā 12 ʻApelila 2021. Ua ʻike ʻia ʻo ia me ka maʻi leukemia lymphoblastic acute (T-cell subtype) me ka intracranial hemorrhage a me ka maʻi māmā i hōʻoia ʻia e ka iwi iwi MICM hoʻokolokolo ma kahi haukapila nui ma ʻO Chongqing. Ua loaʻa ʻo ia i 3 mau manawa o ka chemotherapy ma kahi haukapila ʻē aʻe, akā ʻaʻole i pane mai ka iwi iwi. I ka hoʻomaka ʻana o Iune, ua nāwaliwali ʻo ia i nā lālā haʻahaʻa ʻelua a ʻaʻole hiki ke hele.

Ma Iulai 1, 2021, ua hoʻokomo ʻia ʻo Yangyang i kā mākou Hematology Department Ward 2. Ua kākau inoa ʻo ia i ka CD7 CAR-T clinical trial ma Iulai 8 a loaʻa iā ia ka autologous CD7 CAR-T cell infusion ma Iulai 26 no ka immunotherapy. He ʻumikūmāono lā ma hope o ka hoʻoulu ʻana, ua hōʻike ʻia ke kala ʻana o ka ʻōpū o ka iwi, a ua hōʻike ʻia ka cytometry kahe i ka 0.07% pohihihi nā lymphoblast T ʻoi ʻole. Ma hope o ka hoʻomaʻamaʻa kino, ua loaʻa hou iā ia ka hiki ke hele kaʻawale. Ma ka lā 31 ma hope o ka hoʻokomo ʻana, ua loaʻa i kona iwi iwi ke kala piha.

I kēia manawa, ua hoʻoneʻe ʻia ʻo Yangyang i Ward 6 o ke Keʻena Hoʻololi ʻo Bone Marrow no ka mālama hou ʻana. Ua ʻōlelo ʻo Kauka Hai mai Ward 6, ua hoʻoikaika ikaika ʻo Yangyang i kāna hana ʻana. Ua mālama ʻia ʻo ia i ka allogeneic hematopoietic stem cell transplantation (mai kona makuakāne) i ka lā 28 Kepakemapa. Ua mahalo nui ʻia nā kūlana i hana ʻia e nā hoa hana o ka 'Oihana Hematology no kāna hoʻololi ʻana.

ʻO kēia mau maʻi, ma mua o ke kākau inoa ʻana i ka CD7 CAR-T clinical trial, hōʻike ʻia me nā hōʻailona like ʻole e like me ka hoʻi hou ʻana o ka post-transplant, T/myeloid dual expression, refractory/resistant acute T-cell leukemia, central nervous system leukemia, intracranial hemorrhage, a maʻi māmā. Ma hope o ka loiloi a me ka mālama ʻana me CD7 CAR-T therapy, ua loaʻa nā mea āpau i ke kala piha ʻana, e hālāwai me nā hopena i manaʻo ʻia.

Ua ʻimi ikaika ʻo Ludaopei Hospital i ke kahua o ka CAR-T therapy a hōʻiliʻili i ka ʻike waiwai i ka hoʻokele CRS. No ka hapanui o ka poʻe i komo, ʻo ka hopena koʻikoʻi loa ʻo ke kuni kiʻekiʻe. "Hiki iaʻu ke hoʻokō i ke kala piha, no laila, ʻaʻohe mea ʻino ke kuni! Makemake au e ʻike hou aku nā poʻe e hiki iā Ludaopei ke hana i ka CAR-T!" wahi a Yangyang mai Fujian i ka wā i hoʻokuʻu ʻia ai.