Leukemia Lymphoblastic Acute (T-ALL)-08

Ua ʻōlelo ʻo Yesheng mai Fujian, "Inā wau i ʻike e pili ana iā CAR-T ma Ludaopei, ua hele mua wau."

I ka mahina ʻo Kepakemapa 2017, ua hoʻomohala ʻo Yesheng i nā ʻōpala maka, e pālahalaha mālie a hoʻohui ʻia i loko o nā pā. Ma ka lā 28 o Pepeluali, 2018, ua hōʻoia ka hoʻokolokolo ʻana i ka iwi iwi i ka "acute T-cell lymphoblastic leukemia" ma hope o nā papa he nui o ka chemotherapy, me ka nānā ʻana i ke koena maikaʻi ʻole. Ua kāpae ʻia nā lāʻau lapaʻau a pau i Iune 2019.

I Mei 2021, ua hōʻike ʻo Yesheng me nā lehulehu ma ka ʻāpana oral-pharyngeal a me ka hoʻonui ʻana i nā ʻāʻī lymph nodes. Ua hōʻoia ka nānā hou ʻana o ka iwi iwi i ka hoʻi hou ʻana o ka maʻi leukemia. Ma Mei 28, ua hoʻoneʻe ʻia ʻo Yesheng i ke Keʻena Hematology ʻElua o ka Halemai Ludaopei no ke komo ʻana. Ma hope o nā hoʻokolohua holoʻokoʻa, ua hoʻoponopono hou ʻia ka maʻi i ka "leukemia acute (T/myeloid biphenotypic)."

ʻAʻole hoʻokahi pōʻaiapuni o ka chemotherapy i kala ʻia i ka iwi iwi. Ma Iulai 27, ua loaʻa iā Yesheng ka CD7 CAR-T cell infusion, a ukali ʻia e ka chemotherapy i hui pū ʻia me ka autologous CD7 CAR-T cell therapy. He ʻumikūmālima lā ma hope o ka hoʻokomo ʻana, ua hōʻike ʻia ka nānā ʻana i ka iwi iwi i ka maʻi koena maikaʻi ʻole, me ka pane ʻana o ka cytokine release syndrome (CRS) ma ka papa 1 a ʻaʻohe hopena ʻino o ke kikowaena.