Leukemia Lymphoblastic Acute (T-ALL)-07
Loaʻa i kahi kaikamahine Miao ke kala piha ʻana ma hope o ka hoʻomaʻamaʻa CAR-T ma hope o ka hoʻihoʻi ʻana ma hope o ka hoʻololi ʻana.
Ua paʻi ʻo Amei, he haumāna puka puka mai Hunan o ka lāhui Miao, i ʻelua pepa SCI. Ma ʻApelila 2, 2020, ua hoʻokomo ʻia ʻo ia i kahi haukapila kūloko ma muli o ke kuni mau. Ua ʻike ʻia ʻo ia me ka maʻi leukemia lymphoblastic acute (T-ALL). Ma hope o nā papa he nui o ka chemotherapy ma ka haukapila o waho, ua mau ke kala ʻana o kona iwi iwi. Ma ka lā 2 o Nowemapa, 2020, ua hana ʻia ʻo ia i ka allogeneic hematopoietic stem cell transplant ma ko mākou halemai (ke kaikunāne a me ke kaikuahine, HLA 7/10 match). Ma hope o ka hoʻololi ʻana, ua hoʻopili maikaʻi ʻia nā cell, a ua hōʻike ʻia nā hoʻokolohua ʻana o ka iwi iwi i ke kala mau ʻana.
Ma Iune 16, 2021 (7 mau mahina ma hope o ka hoʻololi ʻana), ua hōʻike ʻia kahi nānā maʻamau i ka hoʻihoʻi hou ʻana o kāna maʻi leukemia. ʻAʻole hiki i ka chemotherapy ke hoʻomalu i ka maʻi, a ua loaʻa ʻo ia i ka maʻi pneumonia a me ka maʻi maʻi herpes, me nā ʻeha waha ʻeha e paʻakikī ai ka ʻai ʻana. Ua hoʻokomo ʻia ʻo ia i ka papa ʻelua o ke keʻena hematology a ua kākau inoa ʻia i ka CD7 CAR-T clinical trial.
Hāʻawi ka hui lapaʻau o Luna Hoʻokele ʻo Yang Junfang i ka hoʻomaʻamaʻa kūʻē i ka maʻi maʻi, hoʻomaha ʻeha, a me ke kahe koko a me ka platelet. Ma muli o ke kaumaha nui o ka maʻi maʻi (80% pahū i loko o ka iwi iwi a me 97% pahū i loko o ke koko peripheral), ʻaʻole hiki ke hōʻiliʻili i kāna mau pūnaewele. Ua hōʻiliʻili ʻia nā lymphocytes koko peripheral mai ka mea hāʻawi (kona kaikunāne) a hoʻouna ʻia i kahi hui biotech no ka moʻomeheu cell CAR-T.
Ma ʻAukake 10, 2021, ua hoʻokomo hou ʻia nā cell CD7 CAR-T i loaʻa i ka mea hāʻawi. Ma hope o ka hoʻoulu hou ʻana, ua hoʻonui ʻia nā cell CAR-T i 54.64% i loko o ke koko peripheral, me ke kuni wale nō a ʻaʻohe mea nui o ka cytokine release syndrome (CRS) a i ʻole graft-versus-host maʻi (GVHD). ʻO ka nānā ʻana i ka iwi iwi ma ka lā 16 ma hope o ka reinfusion ua hōʻike i ke kala piha, me 54.13% CAR-T cell i loko o ka iwi iwi. I ka lā 36, ua hoʻomau ka iwi iwi i ke kala mau ʻana. I kēia manawa, ua maikaʻi kona ʻano noʻonoʻo, ka hiamoe, a me ka ʻai ʻana, a ke ola maikaʻi nei.
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