Leukemia Lymphoblastic Acute (T-ALL)-06

Loaʻa i kahi maʻi pediatric 2 makahiki me T-ALL ke kala ʻia ma hope o ka hoʻōla ʻana o CAR-T ma hope o ʻumi mau pōʻai o ka chemotherapy koʻikoʻi.

Ua ʻike ʻia ʻo Xiaohong ʻelua makahiki mai Zhejiang i ka maʻi leukemia i ke kauwela i hala. Ma hope o hoʻokahi makahiki o ka mālama ʻana, ua ʻike ka flow cytometry i ka hoʻi hou ʻana, e alakaʻi ana i ka ʻohana e ʻimi i ka immunotherapy CAR-T ma ka Halemai Lu Daopei.

Ma ʻAukake 9, 2020, ua hoʻokomo ʻia ʻo Xiaohong i kahi haukapila o nā keiki ma muli o ka "ʻekolu lā maʻi." Ua ʻike ʻia ka maʻi leukemia lymphoblastic acute (T-ALL). Ma hope o hoʻokahi papa o ka chemotherapy, ua hōʻike ʻia ka morphology o ka iwi iwi i ke kala piha ʻana, a ʻaʻole i ʻike ʻia ka cytometry kahe ʻaʻole nā ​​​​pūnaewele makua ʻole. ʻO ka chemotherapy koʻikoʻi ma hope o nā papa he 11 i mālama i ke kala piha o ka iwi iwi.

Ma Sepatemaba 3, 2021, ua hōʻike ʻia ka ʻoki ʻana o ka iwi iwi i ke kala piha ʻana i ka morphology, akā ua hōʻike ʻia ka flow cytometry he 1.85% malignant immature cell. No ka ʻimi ʻana i ka lāʻau lapaʻau hou, ua hoʻokomo ʻia ʻo Xiaohong i ka Halemai ʻo Yanda Lu Daopei i ka lā 24 o Kepakemapa.

Ma ka noʻonoʻo ʻana i ka wā ʻōpio o Xiaohong a me ka hoʻomau ʻana o ka maʻi ʻoiai ʻoi aku ma mua o ʻumi mau pōʻai o ka chemotherapy koʻikoʻi, ua hoʻoholo ka hui lapaʻau ma ke keʻena ʻelua o ke keʻena hematology e hiki iā Xiaohong ke kākau inoa i ka CD7 CAR-T clinical trial.

Ma Sepatemaba 30, 2021, ua hōʻiliʻili ʻia nā ʻili koko ʻili no ka moʻomeheu cell CAR-T. Ma ʻOkakopa 10, ua loaʻa iā Xiaohong ka chemotherapy regimen FC. Ma ka lā 13 o ʻOkakopa, ua hōʻike ʻia he 5% o ka pahū ʻana i ka morphology, a ʻo ka flow cytometry i hōʻike ʻia he 0.37% malignant immature T cell. Ma ka lā 15 o ʻOkakopa, ua hoʻokomo hou ʻia nā cell CD7 CAR-T.

Ma ka lā 3 o Ianuali (20 mau lā ma hope o ka reinfusion), ua hōʻike ʻia ka ʻoki ʻana i ka iwi iwi i ke kala piha ʻana i ka morphology, me ka ʻike ʻole ʻia o nā cell immature malignant e ka cytometry kahe. Ua hoʻopaʻa ʻia ke kūlana o Xiaohong, a ua hoʻoneʻe ʻia ʻo ia i ke keʻena transplant no ka hoʻomākaukau ʻana no ka hoʻololi ʻana i ka allogeneic hematopoietic stem cell transplant.

ʻAʻole i emi iho ʻo Xiaohong i hoʻokahi makahiki i kona wā i maʻi ai a hoʻomanawanui ʻo ia ma mua o hoʻokahi makahiki o ka lāʻau lapaʻau. ʻO ka holomua o ka hoʻololi ʻana ma hope o ka CD7 CAR-T therapy ua hāʻawi i kahi mea kaua ikaika e lanakila loa ai i ka maʻi.