Lupus Erythematosus (SLE) -03

A watan Agustan 2016, Ms. ‘yar shekara 20 ta samu kananan jajayen aibobi a duk jikinta da yawan zazzabi, kuma tana da karancin adadin platelet, watanni bakwai bayan ta haihu. Bayan gwaje-gwaje da yawa a asibitocin yankin, an gano ta tana dauke da kwayar cutar lupus erythematosus (SLE) a wani asibitin lardi. A watan Oktoba na wannan shekarar ne ta fara karbar magani a asibitin yankinta.

“Shekaru bakwai da suka wuce, sai da na rika zuwa asibiti duk wata domin neman magani, a kai-a kai a yi gwajin jini, gwajin fitsari, da kuma magunguna da allura, amma yanayin ya ci gaba da faruwa, wanda ya yi zafi sosai,” in ji Ms. A kokarinta na jinyar cutar ta, mijin nata ya kai ta asibitoci da dama, amma tsadar kudin bai kawo sauki ga yanayin da take ciki ba. A ƙarshe, ta sami lupus nephritis da ciwon hauka, kuma a cikin Satumba 2022, an yi mata tiyata a kwakwalwa. Jin cewa maganin CAR-T na iya yin maganin SLE, Ms. A ta nemi taimako daga asibitinmu, inda nan da nan tawagar kwararru suka bincikar yanayinta.

Likitan ya bayyana cewa, "Lokacin da aka shigar da wannan majinyaci, sai ta samu matsalar kumburin jiki, da sinadarin proteinuria, da kuma kwayoyin kariya masu kyau. An yi mata maganin hormones na gargajiya da na rigakafi, da kuma magunguna guda bakwai na nazarin halittu, amma babu wanda ya yi tasiri. Ta samu lupus. encephalopathy, hauhawar jini na huhu, fibrosis na huhu, da biopsy na renal sun nuna lupus mai aiki Wannan ya nuna cewa maganin gargajiya da na halitta ba su da tasiri. Idan aka kwatanta da magungunan sinadarai na gargajiya ko ƙwayoyin rigakafi na monoclonal, ƙwayoyin CAR-T na iya shiga shingen nama, rarraba a cikin kyallen takarda, kuma suna yin tasirin cytotoxic, musamman akan ƙwayoyin B ko ƙwayoyin plasma a cikin raƙuman nama wanda ba a iya isa ga ƙwayoyin rigakafi na monoclonal. Idan ba tare da 'tsarin cututtuka' ba, magungunan autoantibodies na majiyyaci suna raguwa sannu a hankali, abubuwan da suka dace suna dawowa daidai, kuma a hankali alamun suna raguwa ko bace." Don haka, majiyyacin ya sami nasarar yin maganin CAR-T.

Ms. A ta ce, “Yanzu jajayen tabo a jikina sun bace, kuma ba na bukatar magungunan hormones ko maganin rigakafi, a da ina yawan yin gwajin jini da fitsari, amma yanzu duk bayan wata shida kawai nake bukata, yanayina gaba daya shi ne. mai girma, kuma dukkan alamu sun kasance al'ada a yau ita ce ziyarar ta uku, kuma sakamakon ziyarar da aka yi a baya na da kyau sosai ga ma'aikatan kiwon lafiya da suka ba ni dama ta biyu a rayuwa.