Tsarin Lupus Erythematosus (SLE) -01

Xiaohuan, mai shekaru 24, ya shafe shekaru uku yana karatun likitanci a wata jami'a, kuma ya shafe kusan shekaru 10 yana fama da cutar lupus erythematosus (SLE). "An gano ni a shekara 10, kuma likitan ya ce yana da matukar wahala a warke, cewa da magani kawai zan iya sarrafa shi," in ji Xiaohuan da murmushi mai zafi. A cikin shekaru goma da suka wuce, dole ne ta je duba-up na wata-wata da takardun magani, kuma ta sha maganin hormone, maganin rigakafi, da ilimin halittu, amma babu wanda ya yi tasiri. Ta yi fama da rashin gashi mai tsanani, rashi da yawa, yawan zazzaɓi, da zafi mai yawa.

Bayan gwaje-gwaje na farko na daban-daban, Xiaohuan ya cika dukkan ka'idoji na asibiti don maganin CAR-T don SLE. Ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ta tsara shirin jiyya bisa yanayinta kuma ta shirya a hankali don tsarin tattara ƙwayoyin. A ranar 28 ga Maris, tarin tantanin halitta guda ɗaya ya fara. A ranar 22 ga Afrilu, ta fara maganin chemotherapy na lymphodepleting. A ranar 28 ga Afrilu, an sake shigar da sel. Kwayoyin T da CAR miliyan 20 da aka gyara sannu a hankali an shigar da su cikin jijiyar Xiaohuan, kai tsaye suna kai hari ga ƙwayoyin lupus B, wanda ya haifar da "daidaicin hari, karya su daya bayan daya".

A ranar 4 ga watan Yuni, rana ta 38 bayan jiko, Xiaohuan ya koma asibiti don bibiya. Sakamakon jarrabawar ya nuna cewa duk alamomi masu mahimmanci sun ragu zuwa jeri na al'ada. "Ba na buƙatar magungunan hormone; kamar rayuwa ta fara," Xiaohuan ya ce cikin farin ciki.