Shawn [Ba a Ba da Sunan Ƙarshe ba] ---- Cutar sankarar bargo B-lymphocytic (B-ALL)

Kyakkyawan gwaji na asibiti na CAR-T yana ceton masu haƙuri na Hong Kong B-ALL.

Shawn, dan shekara 29 ne daga Hong Kong. A cikin Maris 2017, yana da alamun zazzabi, gajiya da kodadde. An gano shi da cutar sankarar bargo ta B-lymphocytic a Asibitin Yariman Wales kuma ya sami induction chemotherapy. A watan Afrilu ya shiga cikakkiyar gafara tare da chemotherapy da radiotherapy. Kuma ba a sami rashin daidaituwa ba a cikin rahoton daidaitawar CSF.

Duk da haka, har zuwa 19 Afrilu 2018, ilimin halittar kasusuwa na kasusuwa ya nuna 10% na gonorrhea na farko da na yara. Likitocin Hong Kong suna tunanin cewa chemotherapy yana da wahala a sanya shi cikin cikakkiyar gafara, CAR-T ce kawai ke da babbar damar yin ta. Bayan shawarwarin likitocin da kwatanta adadin nasara da kokarin da aka samu, Shawn ya zo asibitin Lu Daopei na kasar Sin don halartar gwajin asibiti na CAR-T a ranar 23 ga Afrilu 2018.

Gwajin biopsy na kasusuwa da aka shigar ya nuna cewa baya cikin cikakkiyar gafara kuma CD19, CD20 suna da inganci. Bayan shawarwari da yawa, masu ilimin likitancinmu sun ba da shawarar ya shiga cikin gwajin asibiti na CD19+CD20 CAR-T kafin dashen kasusuwa. A cikin shari'o'in mu na CAR-T 300, cikakken adadin gafara yana kusa da 90%.

A ranar 25 ga Afrilu, an tattara sel na Shawn kuma an aika zuwa dakin gwaje-gwaje na GMP CAR-T don injiniyan kwayoyin halitta. Bayan an gyaggyara ta kwayoyin halittar T-cell, an canza su zuwa “kwayoyin T-cell na chimeric antigen receptor (CAR). CARs sunadaran sunadaran da ke taimaka wa ƙwayoyin T su gane antigen a cikin ƙwayoyin ƙari da aka yi niyya. Bayan da ƙwayoyin CAR T suka girma zuwa isasshen adadin don magani, ana shigar da ƙwayoyin CAR T a cikin su don kawar da ƙwayoyin tumor.

Shawn ya sami 1 hanya na chemotherapy a ranar 6 ga Mayu, wanda shine kwanaki 5 kafin jiko tantanin halitta CAR-T. A watan Mayu. A ranar 11 ga Mayu, an ba da jiko na ƙwayoyin CD19 CAR-T azaman rigakafi na salula. Bayan makonni 4 na kulawa da tallafi da kuma kula da sakamako na gefe, ba a sami matsala ba a cikin rahoton daidaitawar CSF, cytometry na gudana, ƙwayar kasusuwa na kasusuwa, gwajin DNA da rahoton CAR-T ya nuna cewa ya sami cikakkiyar gafara.

Kasancewa cikin cikakkiyar gafara ita ce hanya mafi kyau don komawa Hong Kong don mataki na gaba-dashen jini da kasusuwa.