NS7CAR-T Magungunan Kwayoyin Kwayoyin Yana Nuna Alkawari don Magance R/R T-ALL/LBL

Wani bugu na baya-bayan nan a cikin mujallolin Jini ya kawo kulawa mai mahimmanci ga yuwuwar maganin tantanin halitta na NS7CAR-T don magance cutar sankarar ƙwayar cuta mai ƙwayar cuta ta T-cell (R/R T-ALL) da kuma T-cell lymphoblastic lymphoma (R/R T). - LBL). Binciken, wanda aka gudanar a matsayin gwaji na asibiti na lokaci 1 (ClinicalTrials.gov: NCT04572308), ya kimanta aminci da ingancin wannan ingantaccen magani.

Gwajin ya haɗa da marasa lafiya tare da R / R T-ALL / LBL waɗanda suka karɓi ƙwayoyin NS7CAR-T. Sakamako ya nuna cewa NS7CAR-T ba kawai yana da lafiya ba amma kuma ya nuna aikin rigakafin ƙwayar cuta mai ban sha'awa. Marasa lafiya da aka yi musu magani tare da ƙwayoyin NS7CAR-T sun baje kolin mahimman martani na asibiti, suna ba da shawarar yuwuwar wannan maganin azaman kayan aiki mai ƙarfi akan waɗannan ƙalubalen cutar kansa.

Masu bincike a bayan binciken sun hada da tawagar kwararru daga asibitin Hebei Yanda Lu Daopei da Hebei Senlang Biotechnology Co., Ltd. Binciken da suka yi ya nuna cewa kwayoyin NS7CAR-T na iya samar da su yadda ya kamata ba tare da ƙarin gyare-gyaren kwayoyin halitta ba don hana bayyanar CD7, daidaita tsarin samar da kayan aiki. da kuma inganta aikin far.

Wannan ci gaba a cikin jiyya ta kwayar halitta ta NS7CAR-T ta daidaita tare da ƙoƙarin ci gaba da haɓaka jiyya masu inganci don T-ALL da T-LBL. Kamfaninmu kuma yana ci gaba a cikin wannan filin tare da samfurin CAR-T na mallakarmu, wanda muka yi imanin zai dace da sakamako mai ban sha'awa da aka lura tare da maganin NS7CAR-T.

Sakamakon ƙarfafawa na wannan binciken ya ba da hanya don ƙarin bincike da gwaje-gwaje na asibiti don ƙarfafa rawar sel na NS7CAR-T a cikin maganin sake dawowa ko rashin lafiyar T-cell. Yayin da ake samun ƙarin bayanai, ana fatan nan ba da jimawa ba wannan maganin zai zama daidaitaccen zaɓi ga majinyata da ke fama da waɗannan cututtuka masu tsanani.