Maganin CAR-T na Asibitin Lu Daopei Ƙananan Ƙididdigar CD19 yana Nuna Sakamako masu Alkawari a cikin B-ALL marasa lafiya

A cikin wani bincike mai zurfi da aka gudanar a asibitin Lu Daopei, masu bincike sun ba da rahoton ci gaba mai mahimmanci a cikin maganin cutar sankarar jini mai tsanani na lymphoblastic B (B-ALL) ta hanyar yin amfani da ƙananan maganin CAR-T na CD19. Binciken, wanda ya haɗa da marasa lafiya 51, ya bayyana cewa wannan sabuwar hanyar ba kawai ta sami babban adadin gafartawa (CR) ba amma har ma ya kiyaye ingantaccen bayanin martaba.

Ƙungiyar binciken, karkashin jagorancin Dr. C. Tong daga Sashen Hematology da Dr. AH Chang daga Cibiyar Nazarin Fassara ta Clinical a Makarantar Magungunan Jami'ar Tongji, sun binciki sakamakon gudanar da ƙananan ƙwayoyin CAR-T-kimanin 1. × 10^5/kg-idan aka kwatanta da mafi girman allurai na al'ada. Wannan tsarin yana da nufin daidaita ingancin warkewa tare da rage mummunan sakamako masu illa, musamman cututtukan saki na cytokine (CRS).

Sakamakon binciken ya kasance mai jan hankali. Daga cikin 42 refractory / relapsed B-ALL marasa lafiya, 36 sun sami CR ko CR tare da dawo da ƙidayar da ba ta cika ba (CRi), yayin da duk marasa lafiya tara da ke da ƙarancin ƙwayar cuta (MRD) sun kai MRD negativity. Bugu da ƙari, yawancin marasa lafiya sun sami CRS mai sauƙi zuwa matsakaici kawai, tare da ƙananan lokuta ana sarrafa su yadda ya kamata ta hanyar dabarun sa baki da wuri.

Dokta Tong ya bayyana mahimmancin wannan binciken, yana mai cewa, "Sakamakon ya nuna cewa ƙananan ƙwayar CD19 CAR-T cell far, wanda ke biye da allogeneic hematopoietic stem cell transplantation (allo-HCT), yana ba da zaɓin magani mai mahimmanci ga marasa lafiya da ke da lafiya. iyakantattun hanyoyin. Wannan maganin ba kawai yana ba da ƙimar amsawa mai girma ba amma kuma yana rage haɗarin mummunan sakamako."

Nasarar wannan binciken yana nuna yuwuwar da aka keɓance na CAR-T hanyoyin maganin ƙwayoyin cuta a cikin magance hadaddun cututtukan jini. Asibitin Lu Daopei, wanda ya shahara don aikin sa na farko a fannin rigakafi na salula, ya ci gaba da jagorantar samar da manyan jiyya ga marasa lafiya da ke fama da matsalolin cututtukan jini.

Yayin da binciken ke ci gaba, ƙungiyar bincike tana da kyakkyawan fata game da ƙara inganta sashi da ka'idoji don haɓaka sakamakon haƙuri. An buga sakamakon wannan binciken a cikin mujallarCutar sankarar bargoda kuma samar da kyakkyawan fata ga marasa lafiya B-ALL a duk duniya.