Ingancin Tsawon Lokaci na CD19 CAR T-Cell Therapy a cikin Magance Ciwon Ciwon Ciwon Ciwon Ciwon Jiya
A cikin wani gagarumin ci gaba a fannin ilimin halittar jini, wani binciken da aka yi a baya-bayan nan ya nuna tasiri na dogon lokaci na CD19 chimeric antigen receptor (CAR) T-cell far a cikin marasa lafiya da ke fama da cutar sankarar ƙwayar lymphoblastic mai tsanani (ALL) post-allogeneic hematopoietic stem. dashen kwayar halitta (allo-HSCT). Binciken, wanda ya biyo bayan marasa lafiya na tsawon lokaci, yana ba da cikakken bincike game da sakamakon, yana ba da haske mai mahimmanci game da dorewa da amincin wannan ingantaccen magani.
Binciken ya bi diddigin marasa lafiya da suka yi CD19 CAR T-cell far bayan sun fuskanci koma bayan DUK-HSCT. Sakamakon yana da ban sha'awa, yana nuna cewa yawancin marasa lafiya sun sami cikakkiyar gafara, tare da ci gaba da amsawa a cikin shekaru. Wannan bincike ba wai kawai yana nuna yuwuwar hanyoyin warkewa na CAR T-cell far ba amma kuma yana nuna alamar ci gaba a cikin maganin cututtukan cututtukan jini, musamman ga waɗanda ke da ƙarancin zaɓuɓɓukan magani.
Bugu da ƙari kuma, binciken ya shiga cikin bayanin lafiyar lafiyar lafiyar jiki, yana ba da rahoton abubuwan da za a iya sarrafawa, wanda ya dace da binciken farko. Wannan yana ƙarfafa haɓakar kwarin gwiwa a cikin CAR T-cell far a matsayin magani mai inganci kuma mai inganci don sake dawowa/mai hanawa ALL, musamman a cikin saitin dasawa.
Yayin da fannin rigakafin rigakafi ke ci gaba da bunkasa, wannan binciken ya zama ginshikin bege ga marasa lafiya da ma'aikatan kiwon lafiya, tare da yin alƙawarin makoma inda ƙarin marasa lafiya za su iya samun gafara na dogon lokaci. Abubuwan da aka gano ba wai kawai suna ba da gudummawa ga haɓakar shaidun da ke tallafawa maganin CAR T-cell ba amma har ma sun buɗe hanya don ƙarin bincike don haɓakawa da faɗaɗa amfani da shi a cikin saitunan asibiti.
Tare da wannan ci gaba, ƙungiyar likitocin sun kusanci kusa da canza yanayin yanayin jiyya don cututtukan cututtukan jini, suna ba da sabon bege ga marasa lafiya waɗanda ke fama da waɗannan yanayi masu ƙalubale.