Sabbin hanyoyin CAR-T na Kwayoyin Halitta suna Canza Jiyya na Malignancin Kwayoyin B

A cikin wani bita na baya-bayan nan da aka buga a cikin Journal of the National Cancer Center, masana daga asibitin Lu Daopei, karkashin jagorancin Dr. Peihua Lu, tare da masu haɗin gwiwa daga Jami'ar Texas MD Anderson Cibiyar Cancer, sun ba da haske game da sabon ci gaba a CAR-T. hanyoyin kwantar da hankali don maganin cututtukan ƙwayoyin cuta na B-cell. Wannan cikakken bita ya tattauna hanyoyi da yawa na sababbin hanyoyin, ciki har da juyin halittar CAR-T cell da kuma haɗin gwiwar hanyoyin kwantar da hankali, don inganta inganci da amincin jiyya ga cututtuka irin su lymphoma na Hodgkin (NHL) da kuma cutar sankarar lymphoblastic mai tsanani (ALL). ).

B-cell malignancies yana haifar da ƙalubale masu mahimmanci saboda halayen su na sake dawowa da haɓaka juriya ga hanyoyin kwantar da hankali na al'ada. Gabatarwar ƙwayoyin antigen receptor (CAR) T sun canza yanayin yanayin warkewa, yana ba da sabon bege ga marasa lafiya da ke fuskantar waɗannan cututtukan daji masu ƙarfi. Binciken ya nuna yadda za'a iya ƙera ƙwayoyin CAR T tare da ƙira da yawa na ƙira, gami da abubuwan ci gaba kamar masu karɓa na bispecific da yanki mai ƙima, don haɓaka ƙwayoyin tumor yadda ya kamata da rage yiwuwar sake dawowa.

Asibitin Lu Daopei ya kasance a sahun gaba na binciken kwayar halitta na CAR-T da aikace-aikacen asibiti, yana nuna gagarumar nasara wajen haifar da gafara na dogon lokaci. Shigar da asibitin ya yi a cikin wannan aikin na farko ya nuna jajircewarsa na ci gaba da magance cutar daji da kuma ba da kulawa ta zamani. Binciken ya kuma bincika yuwuwar hada hanyoyin kwantar da hankali na CAR-T tare da wasu jiyya, irin su immunotherapy da hanyoyin kwantar da hankali, don shawo kan hanyoyin juriya da haɓaka sakamakon haƙuri.

Wannan wallafe-wallafen shaida ce ga ƙoƙarin haɗin gwiwar masu bincike na duniya da likitoci a cikin tura iyakokin maganin ciwon daji. Sakamakon binciken yana ba da hangen nesa game da makomar ingantaccen ilimin oncology, inda keɓaɓɓen hanyoyin kwantar da hankali da sabbin hanyoyin kwantar da hankali za su iya canza rayuwar marasa lafiya da ke fama da cutar tantanin halitta B. Gudunmawar da asibitin Lu Daopei ke bayarwa ga wannan fanni wani ginshiƙi ne na bege, wanda ke haifar da bunƙasa hanyoyin samar da lafiya da inganci don maganin cutar kansa.