Myasthenia gravis-02

Labarin Magani na Li Ming Myasthenia Gravis

Li Ming, malami mai shekaru 35, ya fara samun alamun cutar myasthenia gravis (MG) shekaru uku da suka wuce. Da farko, ya lura da ptosis (faɗowar fatar ido) da wahalar magana, amma a hankali alamun sun ci gaba zuwa raunin tsoka gabaɗaya, yana sa har ayyukan yau da kullun suna ƙalubalanci. Duk da shan jiyya daban-daban, ciki har da steroids da immunosuppressants, alamunsa sun kasance marasa sarrafawa.

Ta hanyar gabatarwar abokinsa, Li Ming ya isa asibitin Lu Daopei don shiga gwajin asibiti na CAR-T. Ƙwararrun masana sun gudanar da cikakken nazarin alamunsa kuma sun shirya shi don maganin CAR-T.

Tsarin Jiyya:

1. Matakin Shirye-Shirye: Kafin a yi maganin, Li Ming ya yi cikakken kimanta lafiyar lafiya. Likitoci sun ware ƙwayoyin T daga jikinsa kuma sun canza su ta hanyar gado a cikin dakin gwaje-gwaje don bayyana masu karɓar antigen na chimeric (CAR) da ke niyya takamaiman antigens masu alaƙa da myasthenia gravis.

2. Fadada Kwayoyin Halitta: An fadada ƙwayoyin CAR-T da aka gyara a cikin dakin gwaje-gwaje don tabbatar da isasshen adadin don magani.

3. Gyaran Chemotherapy: Kafin jiko tantanin halitta ta CAR-T, Li Ming ya sha maganin chemotherapy na tsawon mako guda don rage yawan adadin lymphocytes da ke cikin jikinsa, yana samar da yanayi mai kyau don ƙwayoyin CAR-T suyi aiki yadda ya kamata.

4. CAR-T Cell Jiko: Bayan kammala chemotherapy, Li Ming an kwantar da shi a asibiti don karɓar jiko na CAR-T. An gudanar da wannan tsari a ƙarƙashin kulawa mai zurfi don hana yiwuwar illa.

Sakamakon Jiyya:

1. Amsa na ɗan gajeren lokaci: A cikin makon farko bayan jiko, Li Ming ya sami zazzabi mai sauƙi da gajiya, halayen ɗan gajeren lokaci na gama gari ga maganin ƙwayoyin cuta na CAR-T. Bayan makonni biyu, ptosis da wahalar magana sun inganta sosai, kuma ƙarfinsa ya fara dawowa.

2. Inganta Tsakanin Wa'adi: Bayan watanni biyu, alamun Li Ming sun ragu sosai. Ya sami damar ci gaba da ayyukan koyarwa na yau da kullun, ingancin aikinsa ya inganta, kuma yanayin rayuwarsa ya nuna haɓaka sosai.

3. Tasirin Dogon Lokaci: Watanni uku bayan jinya, Li Ming ya daina dogaro da magungunan da suka gabata. Binciken da aka yi a baya ya nuna cewa tsarin garkuwar jikinsa yana cikin yanayi mai kyau, ba tare da wani mummunan sakamako ba.

Ta hanyar maganin ƙwayoyin cuta na CAR-T, Li Ming's myasthenia gravis ana sarrafa shi sosai. "Ina matukar godiya ga maganin CAR-T da tawagar likitocin da suka sadaukar domin kokarinsu," in ji Li Ming cikin kuka, yana girgiza hannun likitan bayan sallamar.