Multiple Myeloma(MM)-02

Majinyacin Italiyanci Yana Neman Jiyya kuma Ana Warkar da Myeloma da yawa tare da CAR-T Therapy

Cinty, mace mai shekaru 66, an gano ta da sarkar haske mai lamba lambda myeloma, mataki na ISS, a Italiya a watan Oktoba 2018. Bayan karbar 4 hawan keke na VTD regimen chemotherapy, ta ci gaba da karaya a gefe na uku na clavicle kuma na gefe neuropathy. Neman ƙarin magani mai inganci, an yi mata dashen kwayoyin halitta na autologous a watan Mayu 2019 da Nuwamba 2019, ta sami cikakkiyar gafara, kuma an kiyaye ta akan lenalidomide na baka.

Koyaya, a cikin watan Agusta 2020, binciken PET/CT na bin diddigin ya nuna sabon lalata kashi da haɓaka cikin sauri a cikin sarƙoƙin haske na jini. Kwayar ƙwayar kasusuwa ya nuna ci gaban cututtuka, kuma gwajin FISH ya nuna sabon rashin lafiyar cytogenetic: t (11;14). Bayan zagayowar 4 na tsarin chemotherapy na DVD wanda ya fara a watan Satumba na 2020, ba a shawo kan cutar ta kuma ta ci gaba. Duk da sauyawa zuwa 3 hawan keke na tsarin PCd, ciwon ƙashinta ya ci gaba da ci gaba da tsanantawa. Bayan da ta gaji da yawa sanannun jiyya a duniya kuma an yi mata dashen kwayoyin halitta guda biyu, ta sami juriya ga magunguna da yawa.

Bayan da ta fahimci muhimmancin gwajin asibiti na CAR-T a asibitin Ludaopei ta hanyar bayanan yanar gizo, ta nemi takardar visa kuma ta isa kasar Sin a watan Maris na 2021. Bayan wata guda da keɓe, an kwantar da ita a Asibitin Yanda Ludaopei a ranar 22 ga Afrilu. 2021. Bayan jerin gwaje-gwaje da gwaje-gwajen cututtuka, ta sami jiko na ƙwayoyin BCMA CAR-T bayan FC chemotherapy preconditioning a watan Mayu na wannan shekarar. Bayan jiko, alamunta masu mahimmanci sun tabbata, kuma ba ta sami wani tasiri mai mahimmanci ba sai ƙananan zazzabi. Kumburi na ƙananan gaɓoɓinta ya ragu a hankali, kuma ta yi farin cikin ganin gaba ɗaya lafiyarta ta inganta.

Wata daya bayan jiko na CAR-T, sakamakon gwajin Cinty ya nuna: Ƙididdigar furotin na fitsari na 24-hour a 50 MG / rana, an rage mahimmanci daga matakan shiga; sarƙoƙin haske na jini kyauta: FLC-κ a 4.58 mg/L da FLC-λ a 0.61 mg/L; kuma kimantawar kasusuwa na kasusuwa bai nuna wani muhimmin ƙwayoyin plasma ba. An tantance ta a asibiti a matsayin tana da cikakkiyar gafara (CR).

A halin yanzu, bayan watanni takwas da komawa Italiya, ciwon baya na Cinty da kumburin ƙafar ƙafa biyu sun ɓace gaba ɗaya, kuma tana cikin koshin lafiya. Daga dubban mil mil, Cinty ta nuna matukar godiya ga tawagar da ke asibitin Yanda Ludaopei da darakta Zhang Xian.

Wadannan lokuta guda biyu na asibiti daga asibitin Ludaopei sun nuna cewa ko da marasa lafiya da ƙananan ko rashin bayyanar BCMA a cikin myeloma da yawa na iya samun tasiri mai kyau tare da BCMA CAR-T cell far. Wannan yana wakiltar ci gaba a cikin jiyya na CAR-T don yawancin myeloma, yana kawo sabon bege ga marasa lafiya tare da ci-gaba da cututtukan ƙwayoyin cuta na plasma da kuma myeloma da yawa.