Yada manyan B-cell lymphoma (DLBCL), NOS, GCB subtype, na farko na tsakiya na tsakiya lymphoma-01

A watan Disamba na 2019, Mista Wang, malami daga arewa maso gabashin China, ya fara samun ciwon kai. A ranar 19 ga Disamba, 2019, gwaje-gwajen bincike sun nuna mai zuwa: PET-CT ya nuna inuwa mai yawa tare da haɓaka haɓakar FDG mai mahimmanci a cikin lobe na gaba na hagu da yankin gwiwa na corpus callosum (kimanin 3.4 * 1.9 cm, SUVmax=34.4). Biopsy da immunohistochemistry sun tabbatar da yada manyan ƙwayoyin lymphoma B-cell (DLBCL, NOS, GCB subtype), tare da nau'in immunophenotype mai nuna Ki67 (50%+), CD19 (+), CD20 (+), PAX5 (+), CD79(+), MUM1 (+), BCL (+), CD10 (-/+), CD2 (ƙananan +). Binciken ruwa na cerebrospinal ya bayyana 6% ƙananan ƙwayoyin lymphoid marasa girma tare da sauye-sauyen yanayi. Sakamakon ganewar asali shine lymphoma na tsarin tsakiya na farko (DLBCL, GCB subtype).

Bayan binciken zaɓuɓɓukan jiyya ta kan layi, Mista Wang ya koya game da iyawar asibitin Lu Dao Pei na rigakafi kuma cikin gaggawa ya nemi gwaninta. Bayan gwaje-gwajen jiki sosai da bincike mai zurfi daga ƙungiyar kwararrun asibitin, an yanke shawarar cewa Mr. Wang zai shiga cikin gwajin asibiti don maganin CART, musamman ta amfani da ƙwayoyin CD19 CART. Ya sami jiko na CD19 CAR-T na autologous a ranar 24 ga Afrilu, 2023. Zuwa ranar 30 ga Yuli, 2023, an tantance shi ya sami cikakkiyar gafara (CR) kuma tun daga lokacin ya dawo rayuwa ta yau da kullun.