Yada manyan B-cell lymphoma(DLBCL) -03

A cikin Maris 2021, Mr. Wang (pseudonym) ba zato ba tsammani ya ji ciwon ƙananan ciki, da farko kuskuren rashin jin daɗi na ciki, kuma bai nemi kulawar likita ba da sauri. A cikin watanni biyu masu zuwa, ya sha fama da alamun ciwon ciki na dama, wanda hakan ya sa ya nemi shawarar likita a wani asibiti na yankin. Binciken CT ya nuna rashin daidaituwa a cikin hanji da kuma kara girman nodes na retroperitoneal.

Likitoci sun ba da shawarar colonoscopy da biopsy don ƙarin ganewar asali, wanda ya tabbatar da "yaɗa manyan ƙwayoyin lymphoma B-cell," wani mummunan ƙwayar cuta wanda aka fi sani da lymphoma. PET-CT ya kara tabbatar da yaduwar nodular hypermetabolic raunuka a cikin jikinsa, tare da mafi girman ma'auni 4.3 * 4.1 * 4.5cm.

Tare da tallafin danginsa, Mr. Wang ya yi amfani da hanyoyin R-CHOP chemotherapy sau hudu. Wani bin PET-CT bayan chemotherapy ya nuna juzu'i.

Duk da haka, magungunan da suka biyo baya sun haifar da matsaloli masu tsanani ga Mr. Wang, irin su toshewar hanji, ɓarna, da kuma m peritonitis. Likitocin ciki na ciki da likitocin da ke halartar likitoci sun haɗa kai kan shirin tiyata, suna yin gyaran hanji da magudanar ruwa, tare da kulawar tallafi na alama, yadda ya kamata ke sarrafa alamun cututtukan ciki.

Binciken PET-CT na gaba ya nuna ƙarar raunuka da girma. Don mafi kyawun kawar da ƙwayoyin ƙwayar cuta, likitoci sun daidaita tsarin tsarin chemotherapy mai ƙarfi kuma sun ba da shawarar dashen kwayar cutar hematopoietic.

Da yake fuskantar jerin koma baya, Mr. Wang ya sha wahala sosai ta jiki da ta zuciya yayin da yanayinsa ya tsananta. An lura da kutsewar ƙwayar cuta a wurare da yawa, tare da sabbin raunukan nodular hypermetabolic da aka ɓullo da su suna haɓaka yankin da ke da cutar kansa sosai. Sakamakon ciwace-ciwacen da ake samu a duk fadin jikinsa, Mista Wang ya sha fama da matsananciyar ciwon jiki, wanda hakan ya sa yakan yi masa wuyar kwanciya barci da jin zafi.

A cikin bacin rai, Mista Wang ya koyi game da CAR-T far, wani labari na CAR-T cell immunotherapy wanda aka tsara musamman don marasa lafiya tare da sake dawowa ko ƙwayoyin lymphoma B-cell.

Kafin a sha maganin CAR-T, ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar cuta a cikin yankin inguinal na dama ya nuna CD19 da CD20 mai kyau, yana ba da maƙasudin maƙasudin maganin CAR-T. Farfesa Yu ya shirya cikakken gwajin lafiyar jiki, wanda ya kai ga samar da wani tsarin kula da CAR-T na mutum na Mr. Wang.

A ranar 25 ga Yuli, 2022, Mr. Wang ya sami jiko na CD19/20 CAR-T a asibiti, tare da aikin yana tafiya lafiya. Kusa da kulawa da kulawa mai tsauri yana sarrafa mummunan halayen bayan jiko ba tare da rikitarwa masu barazanar rai ba.

A cikin kasa da watanni uku, zuwa ranar 10 ga Oktoba, 2022, binciken da aka yi na PET-CT ya tabbatar da cikakkiyar gafara, tare da ƙima gabaɗaya yana nuna gagarumin ci gaba a matsayin lafiyarsa.

A yayin bin diddigin, Mista Wang yana yin gwajin CT, MRI, ko PET-CT akai-akai, duk yana tabbatar da cikakken matsayin sa. Ya zuwa yanzu, lafiyarsa na nan da kyau, wanda ya zarce cikakken lokacin gafara sama da watanni 14.