M cutar sankarar bargo ta Lymphoblastic (T-ALL) -10

Wani yaro dan shekara 13 mai suna Yangyang daga Panzhihua na lardin Sichuan, an yi masa tiyatar CAR-T sannan aka yi masa dashe.

Yangyang an gabatar da shi da farko tare da "raguwa a cikin jiki tare da gajiya" a ranar 12 ga Afrilu, 2021. An gano shi da cutar sankarar lymphoblastic mai tsanani (T-cell subtype) tare da zubar da jini na ciki da ciwon huhu da aka tabbatar ta hanyar duban kasusuwa na MICM a wani babban asibiti Chongqing. An yi masa cycle 3 na chemotherapy a wani asibiti, amma kasusuwa bai amsa ba. A farkon watan Yuni, ya sami rauni a cikin ƙananan gaɓɓai kuma ya kasa tafiya.

A ranar 1 ga Yuli, 2021, an shigar da Yangyang a Sashen mu na Hematology Ward 2. Ya yi rajista a cikin gwajin asibiti na CD7 CAR-T a ranar 8 ga Yuli kuma ya karɓi jiko tantanin halitta CD7 CAR-T a kan ga Yuli 26 don rigakafi. Kwanaki goma sha shida bayan jiko, ilimin halittar kasusuwa na kasusuwa ya nuna gafara, kuma cytometry mai gudana ya nuna 0.07% m m m m T lymphoblasts. Bayan gyaran jiki, ya dawo da ikon yin tafiya da kansa. A rana ta 31 bayan jiko, kasusuwan kasusuwa sun sami cikakkiyar gafara.

A halin yanzu, an mayar da Yangyang zuwa Ward 6 na sashen dashen kasusuwan kasusuwa don ci gaba da jinya. Dr. Hai daga Ward 6 ya bayyana cewa Yangyang ya kasance mai bayar da hadin kai da fata a duk tsawon jinyar da yake yi. An yi masa dashen kwayar halitta ta allogeneic hematopoietic stem cell (daga mahaifinsa) a ranar 28 ga Satumba. An yaba da yanayin da abokan aikin Sashen Hematology suka kirkira don dashen dashensa.

Wadannan marasa lafiya, kafin yin rajista a cikin CD7 CAR-T gwajin gwaji, an gabatar da su tare da bayyanar cututtuka daban-daban irin su sake dawowa bayan dasawa, T / myeloid dual expression, refractory / resistant m T-cell cutar sankarar bargo, tsakiyar jijiya cutar sankarar bargo, intracranial hemorrhage, da kuma ciwon huhu. Bayan kimantawa da jiyya tare da CD7 CAR-T far, duk sun sami cikakkiyar gafara, saduwa da sakamakon da ake sa ran.

Asibitin Ludaopei ya binciko sosai a fagen ilimin CAR-T kuma ya tara gogewa mai yawa wajen sarrafa CRS. Ga mafi yawan mahalarta, mafi munin sakamako shine zazzabi mai zafi. "Zan iya samun cikakkiyar gafara, don haka zazzabi ba kome ba ne! Ina so mutane da yawa su san cewa Ludaopei na iya yin CAR-T!" In ji Yangyang daga Fujian bayan sallamar.