M cutar sankarar bargo ta Lymphoblastic (T-ALL) -07

Yarinyar Miao ta sami cikakkiyar gafara bayan maganin CAR-T bayan koma bayan dasawa.

Amei, dalibin digiri na biyu daga Hunan na kabilar Miao, ya buga takardun SCI guda biyu. A ranar 2 ga Afrilu, 2020, an kwantar da ita a wani asibitin lardi sakamakon zazzafar zazzaɓi. Binciken bargon kasusuwa ya gano ta da cutar sankarar bargo ta lymphoblastic (T-ALL). Bayan darussa da yawa na chemotherapy a asibiti na waje, ƙashin ƙashinta ya kasance cikin jin daɗi. A ranar 2 ga Nuwamba, 2020, an yi mata dashen kwayar halitta na allogeneic hematopoietic stem cell a asibitin mu ('yar'uwa ga 'yar'uwa, wasan HLA 7/10). Bayan dasawa, ƙwayoyin da aka dasa su cikin nasara, da kuma bin diddigin binciken ƙwayar kasusuwa sun nuna juriya mai dorewa.

A ranar 16 ga Yuni, 2021 (watanni 7 bayan dasawa), binciken da aka yi na yau da kullun ya nuna cikakkiyar koma bayan cutar sankarar ta. Chemotherapy na baya ya kasa shawo kan cutar, kuma ta kamu da ciwon huhu da ƙwayar cuta ta herpes, tare da gyambon baki mai raɗaɗi wanda ke da wuya ta haɗiye. An shigar da ita a sashi na biyu na sashin ilimin halittar jini kuma ta shiga cikin gwajin asibiti na CD7 CAR-T.

Tawagar likitocin Darakta Yang Junfang sun ba da maganin rigakafin kamuwa da cuta, da rage radadi, da yawan jini da karin jini. Saboda yawan nauyin ƙari (80% fashewa a cikin bargon kashi da 97% fashewa a cikin jini na gefe), ba zai yiwu a tattara kwayoyinta ba. An tattara ƙwayoyin lymphocytes na jini na gefe daga mai bayarwa (dan uwanta) kuma an aika zuwa wani kamfani na biotech don al'adar kwayar halitta ta CAR-T.

A ranar 10 ga Agusta, 2021, an sake dawo da sel CD7 CAR-T masu bayarwa. Bayan sake dawowa, ƙwayoyin CAR-T sun faɗaɗa zuwa 54.64% a cikin jini na gefe, tare da zazzaɓi kawai kuma babu wani muhimmin ciwo na saki na cytokine (CRS) ko cutar da ake kira graft-versus-host (GVHD). Gwajin kasusuwa a ranar 16 bayan sake dawowa ya nuna cikakkiyar gafara, tare da 54.13% CAR-T Kwayoyin a cikin kasusuwa. A rana ta 36, ​​kasusuwan kasusuwa sun ci gaba da nuna juriya mai dorewa. A halin yanzu, yanayin tunaninta, barci, da sha'awar ci suna da kyau, kuma tana samun murmurewa sosai.